4LL5
Crystal Structure of Pim-1 in complex with the fluorescent compound SKF86002
Summary for 4LL5
Entry DOI | 10.2210/pdb4ll5/pdb |
Related | 4LM5 4LMU 4LUD 4LUE |
Descriptor | Serine/threonine-protein kinase pim-1, 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, GLYCEROL, ... (5 entities in total) |
Functional Keywords | co-crystallization, skf86002, fluorescence, inhibitor screening, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34893.53 |
Authors | Parker, L.J.,Tanaka, A.,Handa, N.,Honda, K.,Tomabechi, Y.,Shirouzu, M.,Yokoyama, S. (deposition date: 2013-07-09, release date: 2014-02-12, Last modification date: 2023-11-08) |
Primary citation | Parker, L.J.,Taruya, S.,Tsuganezawa, K.,Ogawa, N.,Mikuni, J.,Honda, K.,Tomabechi, Y.,Handa, N.,Shirouzu, M.,Yokoyama, S.,Tanaka, A. Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70:392-404, 2014 Cited by PubMed: 24531473DOI: 10.1107/S1399004713028654 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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