4LAJ
Crystal structure of HIV-1 YU2 envelope gp120 glycoprotein in complex with CD4-mimetic miniprotein, M48U1, and llama single-domain, broadly neutralizing, co-receptor binding site antibody, JM4
Summary for 4LAJ
Entry DOI | 10.2210/pdb4laj/pdb |
Related | 4JZW 4JZZ |
Related PRD ID | PRD_001094 |
Descriptor | HIV-1 YU2 gp120 envelope glycoprotein, CD4-mimetic miniprotein M48U1, Llama single domain antibody, JM4, ... (7 entities in total) |
Functional Keywords | cd4-induced antibody, hiv-1 neutralizing antibody, hiv-1 gp120 reactive, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Human immunodeficiency virus 1 (HIV-1) More |
Total number of polymer chains | 12 |
Total formula weight | 243358.81 |
Authors | Acharya, P.,Luongo, T.S.,Kwong, P.D. (deposition date: 2013-06-20, release date: 2013-08-14, Last modification date: 2023-11-15) |
Primary citation | Acharya, P.,Luongo, T.S.,Georgiev, I.S.,Matz, J.,Schmidt, S.D.,Louder, M.K.,Kessler, P.,Yang, Y.,McKee, K.,O'Dell, S.,Chen, L.,Baty, D.,Chames, P.,Martin, L.,Mascola, J.R.,Kwong, P.D. Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites. J.Virol., 87:10173-10181, 2013 Cited by PubMed: 23843638DOI: 10.1128/JVI.01332-13 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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