4L8M
Human p38 MAP kinase in complex with a Dibenzoxepinone
Summary for 4L8M
Entry DOI | 10.2210/pdb4l8m/pdb |
Related | 3QUD 3QUE |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, N-[2-fluoro-5-({9-[2-(morpholin-4-yl)ethoxy]-11-oxo-6,11-dihydrodibenzo[b,e]oxepin-3-yl}amino)phenyl]benzamide, ... (4 entities in total) |
Functional Keywords | protein kinase, selective p38 inhibitor, sar, dibenzoxepinone derivative, dibenzoxepinone, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42421.40 |
Authors | Richters, A.,Mayer-Wrangowski, S.C.,Gruetter, C.,Rauh, D. (deposition date: 2013-06-17, release date: 2013-10-30, Last modification date: 2023-09-20) |
Primary citation | Baur, B.,Storch, K.,Martz, K.E.,Goettert, M.I.,Richters, A.,Rauh, D.,Laufer, S.A. Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood. J.Med.Chem., 56:8561-8578, 2013 Cited by PubMed: 24131218DOI: 10.1021/jm401276h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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