4L2Y
Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d
Summary for 4L2Y
Entry DOI | 10.2210/pdb4l2y/pdb |
Related | 4L1B 4L23 |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 3-amino-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol, ... (6 entities in total) |
Functional Keywords | atp binding, signaling protein-transferase-inhibitor complex, signaling protein/transferase/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 164144.06 |
Authors | Zhang, J.,Zhao, Y.L.,Chen, Y.Y.,Huang, M.,Jiang, F. (deposition date: 2013-06-05, release date: 2014-01-01, Last modification date: 2023-09-20) |
Primary citation | Zhao, Y.,Zhang, X.,Chen, Y.,Lu, S.,Peng, Y.,Wang, X.,Guo, C.,Zhou, A.,Zhang, J.,Luo, Y.,Shen, Q.,Ding, J.,Meng, L.,Zhang, J. Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett, 5:138-142, 2014 Cited by PubMed: 24900786DOI: 10.1021/ml400378e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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