4KY2
Transthyretin in complex with the fluorescent folding sensor (E)-7-hydroxy-3-(4-hydroxy-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one
Summary for 4KY2
Entry DOI | 10.2210/pdb4ky2/pdb |
Related | 1DVS 3CN0 3CN1 3CN3 3CN4 |
Descriptor | Transthyretin, 7-hydroxy-3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]-4-methyl-2H-chromen-2-one (3 entities in total) |
Functional Keywords | tetramer, hormone, transport protein, t4, retinol binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28199.43 |
Authors | Connelly, S.,Wilson, I.A.,Choi, S. (deposition date: 2013-05-28, release date: 2013-08-28, Last modification date: 2023-09-20) |
Primary citation | Myung, N.,Connelly, S.,Kim, B.,Park, S.J.,Wilson, I.A.,Kelly, J.W.,Choi, S. Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chem.Commun.(Camb.), 49:9188-9190, 2013 Cited by PubMed: 23989101DOI: 10.1039/c3cc44667k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.13 Å) |
Structure validation
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