4KV8

Crystal structure of HIV RT in complex with BILR0355BS

Summary for 4KV8

• Entry DOI: 10.2210/pdb4kv8/pdb
• Related: 1RTH
• Related PRD ID: PRD_900003
• Descriptor: HIV Reverse transcriptase P66, HIV Reverse transcriptase P51, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: nucleotidyltransferase, transferase
• Biological source: HIV-1 M:B_HXB2R (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 117479.61

Authors

Coulombe, R. (deposition date: 2013-05-22, release date: 2013-07-31, Last modification date: 2024-02-28)

• Primary citation: Laplante, S.R.,Bilodeau, F.,Aubry, N.,Gillard, J.R.,O'Meara, J.,Coulombe, R.; N- versus O-alkylation: Utilizing NMR methods to establish reliable primary structure determinations for drug discovery.; Bioorg.Med.Chem.Lett., 23:4663-4668, 2013; PubMed: 23809849; DOI: 10.1016/j.bmcl.2013.06.007

Experimental method

X-RAY DIFFRACTION (2.3 Å)