4KNB
C-Met in complex with OSI ligand
Summary for 4KNB
Entry DOI | 10.2210/pdb4knb/pdb |
Descriptor | Hepatocyte growth factor receptor, 7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine, GAMMA-BUTYROLACTONE, ... (4 entities in total) |
Functional Keywords | protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 4 |
Total formula weight | 132419.11 |
Authors | Wang, J.,Steinig, A.G.,Li, A.H.,Chen, X.,Dong, H.,Ferraro, C.,Jin, M.,Kadalbajoo, M.,Kleinberg, A.,Stolz, K.M.,Tavares-Greco, P.A.,Wang, T.,Albertella, M.R.,Peng, Y.,Crew, L.,Kahler, J. (deposition date: 2013-05-09, release date: 2014-04-30, Last modification date: 2024-02-28) |
Primary citation | Steinig, A.G.,Li, A.H.,Wang, J.,Chen, X.,Dong, H.,Ferraro, C.,Jin, M.,Kadalbajoo, M.,Kleinberg, A.,Stolz, K.M.,Tavares-Greco, P.A.,Wang, T.,Albertella, M.R.,Peng, Y.,Crew, L.,Kahler, J.,Kan, J.,Schulz, R.,Cooke, A.,Bittner, M.,Turton, R.W.,Franklin, M.,Gokhale, P.,Landfair, D.,Mantis, C.,Workman, J.,Wild, R.,Pachter, J.,Epstein, D.,Mulvihill, M.J. Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases. Bioorg.Med.Chem.Lett., 23:4381-4387, 2013 Cited by PubMed: 23773865DOI: 10.1016/j.bmcl.2013.05.074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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