4KNB

C-Met in complex with OSI ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1RU A 1401

Chain	Residue
A	ALA1108
A	TYR1230
C	GLU1306
A	LEU1140
A	PRO1158
A	TYR1159
A	MET1160
A	LYS1161
A	GLY1163
A	MET1211
A	ALA1221

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GBL A 1402

Chain	Residue
A	SER1331
A	HOH1522
C	GLN1304
C	PRO1305
C	GLU1306

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GBL A 1403

Chain	Residue
A	PRO1176
A	PHE1184

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1RU B 1401

Chain	Residue
B	ILE1084
B	ALA1108
B	LEU1140
B	PRO1158
B	TYR1159
B	MET1160
B	LYS1161
B	ARG1208
B	MET1211
B	ALA1221
B	ASP1222
B	TYR1230

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GBL B 1402

Chain	Residue
B	LEU1140
B	LEU1157
B	ALA1221
B	ASP1222
B	PHE1223
B	ALA1226

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 1RU C 1401

Chain	Residue
C	ILE1084
C	ALA1108
C	LEU1140
C	PRO1158
C	TYR1159
C	MET1160
C	LYS1161
C	GLY1163
C	ARG1208
C	ASN1209
C	MET1211
C	ALA1221
C	TYR1230

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1RU D 1401

Chain	Residue
D	ILE1084
D	ALA1108
D	LEU1140
D	PRO1158
D	TYR1159
D	MET1160
D	LYS1161
D	ARG1208
D	ASN1209
D	MET1211
D	ALA1221

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGHFGCVYhGtlldndgkkih.......CAVK

Chain	Residue	Details
A	ILE1084-LYS1110

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCML

Chain	Residue	Details
A	PHE1200-LEU1212

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP1204
B	ASP1204
C	ASP1204
D	ASP1204

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE1084
B	ILE1084
C	ILE1084
D	ILE1084

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	LYS1110
B	LYS1110
C	LYS1110
D	LYS1110

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:12475979

Chain	Residue	Details
A	TYR1230
B	TYR1230
C	TYR1230
D	TYR1230

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12475979

Chain	Residue	Details
A	TYR1234
B	TYR1234
C	TYR1234
D	TYR1234

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:1655790

Chain	Residue	Details
A	TYR1235
B	TYR1235
C	TYR1235
D	TYR1235

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	THR1289
B	THR1289
C	THR1289
D	THR1289

---