4K8B

Crystal structure of HCV NS3/4A protease complexed with inhibitor

Summary for 4K8B

Entry DOI	10.2210/pdb4k8b/pdb
Related PRD ID	PRD_001064
Descriptor	NS3 protease, Nonstructural protein, ZINC ION, ... (6 entities in total)
Functional Keywords	protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Hepatitis C virus More
Total number of polymer chains	4
Total formula weight	42407.13
Authors	Nar, H. (deposition date: 2013-04-18, release date: 2014-03-26, Last modification date: 2023-11-08)
Primary citation	Laplante, S.R.,Nar, H.,Lemke, C.T.,Jakalian, A.,Aubry, N.,Kawai, S.H. Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease. J.Med.Chem., 57:1777-1789, 2014 Cited by PubMed: 24144444 DOI: 10.1021/jm401338c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation