4K8B
Crystal structure of HCV NS3/4A protease complexed with inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006508 | biological_process | proteolysis |
A | 0008233 | molecular_function | peptidase activity |
A | 0008236 | molecular_function | serine-type peptidase activity |
A | 0016020 | cellular_component | membrane |
A | 0019062 | biological_process | virion attachment to host cell |
A | 0019087 | biological_process | transformation of host cell by virus |
A | 0033644 | cellular_component | host cell membrane |
A | 0044423 | cellular_component | virion component |
A | 0046718 | biological_process | symbiont entry into host cell |
A | 0046872 | molecular_function | metal ion binding |
B | 0006508 | biological_process | proteolysis |
B | 0008233 | molecular_function | peptidase activity |
B | 0008236 | molecular_function | serine-type peptidase activity |
B | 0016020 | cellular_component | membrane |
B | 0019062 | biological_process | virion attachment to host cell |
B | 0019087 | biological_process | transformation of host cell by virus |
B | 0033644 | cellular_component | host cell membrane |
B | 0044423 | cellular_component | virion component |
B | 0046718 | biological_process | symbiont entry into host cell |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 201 |
Chain | Residue |
A | CYS97 |
A | THR98 |
A | CYS99 |
A | CYS145 |
A | HOH306 |
site_id | AC2 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 1RR A 202 |
Chain | Residue |
A | ASP81 |
A | ARG123 |
A | VAL132 |
A | LEU135 |
A | LYS136 |
A | GLY137 |
A | SER138 |
A | SER139 |
A | PHE154 |
A | ARG155 |
A | ALA156 |
A | ALA157 |
A | CYS159 |
A | ASP168 |
A | HOH345 |
B | VAL78 |
B | 1RR202 |
A | TYR56 |
A | HIS57 |
A | VAL78 |
A | ASP79 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 203 |
Chain | Residue |
A | ARG11 |
A | GLY15 |
A | ASN27 |
B | ARG11 |
B | GLY15 |
B | ASN27 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 204 |
Chain | Residue |
A | LEU21 |
A | ARG24 |
A | LYS26 |
A | HOH331 |
B | GLN9 |
B | GLY12 |
B | LEU13 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 201 |
Chain | Residue |
B | CYS97 |
B | THR98 |
B | CYS99 |
B | CYS145 |
B | HOH325 |
site_id | AC6 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE 1RR B 202 |
Chain | Residue |
A | TYR56 |
A | ASP79 |
A | 1RR202 |
B | TYR56 |
B | HIS57 |
B | ASP79 |
B | ASP81 |
B | ARG123 |
B | VAL132 |
B | LEU135 |
B | LYS136 |
B | GLY137 |
B | SER138 |
B | SER139 |
B | PHE154 |
B | ARG155 |
B | ALA156 |
B | ALA157 |
B | CYS159 |
B | HOH302 |
B | HOH314 |
B | HOH316 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 203 |
Chain | Residue |
A | GLY12 |
A | LEU13 |
A | LEU14 |
B | ARG24 |
B | LYS26 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 D 301 |
Chain | Residue |
A | GLN28 |
A | GLU30 |
B | GLN28 |
C | ARG228 |
D | ARG228 |