4K8B
Crystal structure of HCV NS3/4A protease complexed with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NS3 protease | polymer | 181 | 19046.7 | 2 | UniProt (Q0ZNA6) Pfam (PF02907) | Hepatitis C virus | |
| 2 | C, D (C, D) | Nonstructural protein | polymer | 12 | 1213.5 | 2 | UniProt (Q81584) UniProt (by SIFTS) (P26663) | Hepatitis C virus | non-structural protein 4A |
| 3 | E, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, J (A, B) | N-(tert-butylcarbamoyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-4-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-L-prolinamide | non-polymer | 685.8 | 2 | BIRD (PRD_001064) Chemie (1RR) | |||
| 5 | G, H, K, L (A, B, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 40520.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1886.7 | |
| All* | Total formula weight | 42407.1 |
