4K8B

Crystal structure of HCV NS3/4A protease complexed with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NS3 protease	polymer	181	19046.7	2	UniProt (Q0ZNA6) Pfam (PF02907) In PDB	Hepatitis C virus
2	C, D	Nonstructural protein	polymer	12	1213.5	2	UniProt (Q81584) UniProt (by SIFTS) (P26663) In PDB	Hepatitis C virus	non-structural protein 4A
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	A, B	N-(tert-butylcarbamoyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-4-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-L-prolinamide	non-polymer		685.8	2	BIRD (PRD_001064) Chemie (1RR)
5	A, B, D	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
6		water	water		18.0	90	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	40520.4
Non-Polymers*	Number of molecules	8
	Total formula weight	1886.7
All*	Total formula weight	42407.1

*Water molecules are not included.