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4JRG

The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor

Summary for 4JRG
Entry DOI10.2210/pdb4jrg/pdb
Related4IPF
DescriptorE3 ubiquitin-protein ligase Mdm2, (3R,4R,5S)-3-(3-chlorophenyl)-4-(4-chlorophenyl)-4-cyano-N-[(3S)-3,4-dihydroxybutyl]-5-(2,2-dimethylpropyl)-D-prolinamide (3 entities in total)
Functional Keywordsprotein-inhibitor complex, pyrrolidine, e3 ubiquitin ligase, p53, nucleus, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceXenopus laevis (clawed frog,common platanna,platanna)
Cellular locationNucleus, nucleoplasm (By similarity): P56273
Total number of polymer chains2
Total formula weight20699.79
Authors
Graves, B.J.,Janson, C.A.,Lukacs, C. (deposition date: 2013-03-21, release date: 2013-07-24, Last modification date: 2024-02-28)
Primary citationDing, Q.,Zhang, Z.,Liu, J.J.,Jiang, N.,Zhang, J.,Ross, T.M.,Chu, X.J.,Bartkovitz, D.,Podlaski, F.,Janson, C.,Tovar, C.,Filipovic, Z.M.,Higgins, B.,Glenn, K.,Packman, K.,Vassilev, L.T.,Graves, B.
Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development.
J.Med.Chem., 56:5979-5983, 2013
Cited by
PubMed: 23808545
DOI: 10.1021/jm400487c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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