4JRG
The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | E3 ubiquitin-protein ligase Mdm2 | polymer | 85 | 9831.4 | 2 | UniProt (P56273) Pfam (PF02201) In PDB | Xenopus laevis (clawed frog common platanna platanna) | Double minute 2 protein, Xdm2, p53-binding protein Mdm2 |
| 2 | A, B | (3R,4R,5S)-3-(3-chlorophenyl)-4-(4-chlorophenyl)-4-cyano-N-[(3S)-3,4-dihydroxybutyl]-5-(2,2-dimethylpropyl)-D-prolinamide | non-polymer | 518.5 | 2 | Chemie (I09) | |||
| 3 | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 105 (UniProt: P56273)
| PDB | External Database | Details |
|---|---|---|
| Leu 50 | Ile 50 | engineered mutation |
| His 92 | Pro 92 | engineered mutation |
| Ile 95 | Leu 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 19662.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1037.0 | |
| All* | Total formula weight | 20699.8 |
