4JRG

The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	E3 ubiquitin-protein ligase Mdm2	polymer	85	9831.4	2	UniProt (P56273) Pfam (PF02201)	Xenopus laevis (clawed frog common platanna platanna)	Double minute 2 protein, Xdm2, p53-binding protein Mdm2
2	C, D (A, B)	(3R,4R,5S)-3-(3-chlorophenyl)-4-(4-chlorophenyl)-4-cyano-N-[(3S)-3,4-dihydroxybutyl]-5-(2,2-dimethylpropyl)-D-prolinamide	non-polymer		518.5	2	Chemie (I09)
3	E, F (A, B)	water	water		18.0	128	Chemie (HOH)

Sequence modifications

A, B: 21 - 105 (UniProt: P56273)

PDB	External Database	Details
Leu 50	Ile 50	engineered mutation
His 92	Pro 92	engineered mutation
Ile 95	Leu 95	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	19662.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1037.0
All*	Total formula weight	20699.8

*Water molecules are not included.