4JRG
The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE I09 A 201 |
| Chain | Residue |
| A | LEU50 |
| A | TYR96 |
| A | HOH331 |
| A | HOH332 |
| A | ILE57 |
| A | MET58 |
| A | HIS69 |
| A | PHE82 |
| A | VAL89 |
| A | LYS90 |
| A | HIS92 |
| A | ILE95 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE I09 B 201 |
| Chain | Residue |
| B | LEU50 |
| B | GLY54 |
| B | MET58 |
| B | HIS69 |
| B | VAL89 |
| B | LYS90 |
| B | HIS92 |
| B | HOH325 |
| B | HOH326 |
