4JPZ

Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin

Summary for 4JPZ

• Entry DOI: 10.2210/pdb4jpz/pdb
• Related: 4JQ0
• Descriptor: Fibroblast growth factor 13, Sodium channel protein type 2 subunit alpha, Calmodulin, ... (5 entities in total)
• Functional Keywords: ef hand and iq motif, ion channel, membrane, transport protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell projection, filopodium . Isoform 1: Nucleus, nucleolus. Isoform 2: Cytoplasm: Q92913; Cell membrane ; Multi-pass membrane protein : Q99250
• Total number of polymer chains: 6
• Total formula weight: 119317.00

Authors

Wang, C.,Chung, B.C.,Yan, H.,Wang, H.G.,Lee, S.Y.,Pitt, G.S. (deposition date: 2013-03-19, release date: 2014-04-16, Last modification date: 2024-02-28)

• Primary citation: Wang, C.,Chung, B.C.,Yan, H.,Wang, H.G.,Lee, S.Y.,Pitt, G.S.; Structural analyses of Ca(2+)/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.; Nat Commun, 5:4896-4896, 2014; PubMed: 25232683; DOI: 10.1038/ncomms5896

Experimental method

X-RAY DIFFRACTION (3.02 Å)