4JPZ
Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, E) | Fibroblast growth factor 13 | polymer | 192 | 21609.6 | 2 | UniProt (Q92913) Pfam (PF00167) | Homo sapiens (human) | FGF-13, Fibroblast growth factor homologous factor 2, FHF-2 |
| 2 | B, E (B, H) | Sodium channel protein type 2 subunit alpha | polymer | 184 | 21036.0 | 2 | UniProt (Q99250) | Homo sapiens (human) | HBSC II, Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.2 |
| 3 | C, F (C, I) | Calmodulin | polymer | 149 | 16852.5 | 2 | UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) | Homo sapiens (human) | CaM |
| 4 | G, H, I, J, K... (C, I) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 5 | O, P, Q, R, S (A, B, C, E, H) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, E: 5 - 192 (UniProt: Q92913)
B, H: 1777 - 1937 (UniProt: Q99250)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Lys 6 | Arg 59 | SEE REMARK 999 |
| Ser 7 | Arg 60 | SEE REMARK 999 |
| Tyr 8 | Arg 61 | SEE REMARK 999 |
| Ser 9 | Pro 62 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Met 1754 | - | expression tag |
| Gly 1755 | - | expression tag |
| Ser 1756 | - | expression tag |
| Ser 1757 | - | expression tag |
| His 1758 | - | expression tag |
| His 1759 | - | expression tag |
| His 1760 | - | expression tag |
| His 1761 | - | expression tag |
| His 1762 | - | expression tag |
| His 1763 | - | expression tag |
| Ser 1764 | - | expression tag |
| Ser 1765 | - | expression tag |
| Gly 1766 | - | expression tag |
| Leu 1767 | - | expression tag |
| Val 1768 | - | expression tag |
| Pro 1769 | - | expression tag |
| Arg 1770 | - | expression tag |
| Gly 1771 | - | expression tag |
| Ser 1772 | - | expression tag |
| His 1773 | - | expression tag |
| Met 1774 | - | expression tag |
| Ala 1775 | - | expression tag |
| Ser 1776 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 118996.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 320.6 | |
| All* | Total formula weight | 119317.0 |
