4JAJ
Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE
Summary for 4JAJ
Entry DOI | 10.2210/pdb4jaj/pdb |
Related | 4JAI |
Descriptor | Aurora kinase A, benzo[c][1,8]naphthyridin-6(5H)-one (3 entities in total) |
Functional Keywords | kinase inhibitor complex, atp-binding, cell cycle, cytoplasm, cytoskeleton, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, protein kinase-like cytoplasm, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 33241.10 |
Authors | Jiang, X.,Josephson, K.,Huck, B.,Goutopoulos, A.,Karra, S. (deposition date: 2013-02-18, release date: 2013-05-22, Last modification date: 2023-09-20) |
Primary citation | Karra, S.,Xiao, Y.,Chen, X.,Liu-Bujalski, L.,Huck, B.,Sutton, A.,Goutopoulos, A.,Askew, B.,Josephson, K.,Jiang, X.,Shutes, A.,Shankar, V.,Noonan, T.,Garcia-Berrios, G.,Dong, R.,Dhanabal, M.,Tian, H.,Wang, Z.,Clark, A.,Goodstal, S. SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg.Med.Chem.Lett., 23:3081-3087, 2013 Cited by PubMed: 23570792DOI: 10.1016/j.bmcl.2013.03.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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