4J5R

TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1 bound to ADP-HPD

Summary for 4J5R

• Entry DOI: 10.2210/pdb4j5r/pdb
• Related: 4J5Q 4J5S
• Descriptor: O-acetyl-ADP-ribose deacetylase 1, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: dna repair, cellular signaling, macro domain, glycohydrolase, poly-adp ribose, parp, adp-ribose, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 34403.66

Authors

Schellenberg, M.J.,Appel, C.D.,Krahn, J.,Williams, R.S. (deposition date: 2013-02-09, release date: 2013-03-27, Last modification date: 2023-09-20)

• Primary citation: Sharifi, R.,Morra, R.,Appel, C.D.,Tallis, M.,Chioza, B.,Jankevicius, G.,Simpson, M.A.,Matic, I.,Ozkan, E.,Golia, B.,Schellenberg, M.J.,Weston, R.,Williams, J.G.,Rossi, M.N.,Galehdari, H.,Krahn, J.,Wan, A.,Trembath, R.C.,Crosby, A.H.,Ahel, D.,Hay, R.,Ladurner, A.G.,Timinszky, G.,Williams, R.S.,Ahel, I.; Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.; Embo J., 32:1225-1237, 2013; PubMed: 23481255; DOI: 10.1038/emboj.2013.51

Experimental method

X-RAY DIFFRACTION (1.25 Å)