4IXV
Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)
Summary for 4IXV
Entry DOI | 10.2210/pdb4ixv/pdb |
Related | 1D3V 1PQ3 4IXU |
Descriptor | Arginase-2, mitochondrial, MANGANESE (II) ION, BENZAMIDINE, ... (6 entities in total) |
Functional Keywords | metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, mitochondrion, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens |
Cellular location | Mitochondrion : P78540 |
Total number of polymer chains | 3 |
Total formula weight | 101818.54 |
Authors | Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Whitehouse, D.,Beckett, P.,Van Zandt, M.C.,Ji, M.K.,Ryder, T.,Jagdmann, R.,Andreoli, M.,Olczak, J.,Mazur, M.,Czestkowski, W.,Piotrowska, W.,Schroeter, H.,Golebiowski, A.,Podjarny, A. (deposition date: 2013-01-28, release date: 2013-12-11, Last modification date: 2023-09-20) |
Primary citation | Golebiowski, A.,Whitehouse, D.,Beckett, R.P.,Van Zandt, M.,Ji, M.K.,Ryder, T.R.,Jagdmann, E.,Andreoli, M.,Lee, Y.,Sheeler, R.,Conway, B.,Olczak, J.,Mazur, M.,Czestkowski, W.,Piotrowska, W.,Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Podjarny, A.,Schroeter, H. Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg.Med.Chem.Lett., 23:4837-4841, 2013 Cited by PubMed: 23886684DOI: 10.1016/j.bmcl.2013.06.092 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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