4IXH
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum
Summary for 4IXH
Entry DOI | 10.2210/pdb4ixh/pdb |
Related | 3FFS |
Descriptor | Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, alpha-beta fold, tim barrel, oxidoreductase |
Biological source | Cryptosporidium parvum More |
Cellular location | Cytoplasm : Q8T6T2 |
Total number of polymer chains | 4 |
Total formula weight | 157366.62 |
Authors | Kim, Y.,Makowska-Grzyska, M.,Gu, M.,Kavitha, M.,Hedstrom, L.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2013-01-25, release date: 2013-04-03, Last modification date: 2023-09-20) |
Primary citation | Gorla, S.K.,Kavitha, M.,Zhang, M.,Chin, J.E.,Liu, X.,Striepen, B.,Makowska-Grzyska, M.,Kim, Y.,Joachimiak, A.,Hedstrom, L.,Cuny, G.D. Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5'-Monophosphate Dehydrogenase. J.Med.Chem., 56:4028-4043, 2013 Cited by PubMed: 23668331DOI: 10.1021/jm400241j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.105 Å) |
Structure validation
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