4ISU

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution.

Summary for 4ISU

• Entry DOI: 10.2210/pdb4isu/pdb
• Descriptor: Glutamate receptor 2, (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid, SULFATE ION, ... (5 entities in total)
• Functional Keywords: ampa receptor ligand-binding domain, glur2-s1s2j, antagonist, membrane protein, membrane protein-antagonist complex, membrane protein/antagonist
• Biological source: Rattus norvegicus (brown rat,rat,rats); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 4
• Total formula weight: 118311.23

Authors

Juknaite, L.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2013-01-17, release date: 2013-03-20, Last modification date: 2023-09-20)

• Primary citation: Juknaite, L.,Sugamata, Y.,Tokiwa, K.,Ishikawa, Y.,Takamizawa, S.,Eng, A.,Sakai, R.,Pickering, D.S.,Frydenvang, K.,Swanson, G.T.,Kastrup, J.S.,Oikawa, M.; Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.; J.Med.Chem., 56:2283-2293, 2013; PubMed: 23432124; DOI: 10.1021/jm301590z

Experimental method

X-RAY DIFFRACTION (2.3 Å)