4ISU
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, C, B) | Glutamate receptor 2 | polymer | 263 | 29221.7 | 4 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (brown rat rat rats) | GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2 |
| 2 | E, P (A, B) | (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid | non-polymer | 282.2 | 2 | Chemie (IKM) | |||
| 3 | F, I, L, M, Q... (A, D, C, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | G, H, J, K, N... (A, D, C, B) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 5 | U, V, W, X (A, D, C, B) | water | water | 18.0 | 446 | Chemie (HOH) |
Sequence modifications
A, D, C, B: 3 - 117 (UniProt: P19491)
A, D, C, B: 120 - 263 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 116886.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1424.5 | |
| All* | Total formula weight | 118311.2 |
