4ISU

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE IKM A 301

Chain	Residue
A	TYR61
A	TYR220
A	HOH510
A	PRO89
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR174
A	GLU193

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	HIS23
A	LYS144
A	ARG148

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 303

Chain	Residue
A	THR174

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 304

Chain	Residue
A	SER194
A	GLU198

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 301

Chain	Residue
D	ARG96
D	SER142

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 303

Chain	Residue
D	SER194
D	GLU198

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 301

Chain	Residue
C	HIS23
C	LYS144
C	ARG148
C	ARG163

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
C	TYR61
C	THR91
C	ARG96
C	SER142

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 303

Chain	Residue
C	GLU198

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 304

Chain	Residue
C	SER140
C	ARG148

---

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE IKM B 301

Chain	Residue
B	TYR61
B	PRO89
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR174
B	GLU193
B	TYR220
B	HOH454
B	HOH466
B	HOH503

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	LYS144
B	ARG148
B	ARG163
D	HIS23

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
B	HIS23
D	LYS144
D	ARG148
D	TRP159

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 304

Chain	Residue
B	THR174

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 305

Chain	Residue
B	SER194
B	GLU198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
D	SER142
D	THR143
D	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
B	PRO89
A	THR91
B	THR91
B	ARG96
B	SER142
B	THR143
B	GLU193
A	ARG96
A	SER142
A	THR143
A	GLU193
D	PRO89
D	THR91
D	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
B	ARG64
B	ARG148
B	LYS240
A	ARG148
A	LYS240
D	ARG64
D	ARG148
D	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
D	ILE121
C	ILE121
B	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
D	SER150
C	SER150
B	SER150

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
D	SER184
C	SER184
B	SER184

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
D	ASN3
C	ASN3
B	ASN3

---