4IP7
Structure of the S12D variant of human liver pyruvate kinase in complex with citrate and FBP.
Summary for 4IP7
Entry DOI | 10.2210/pdb4ip7/pdb |
Descriptor | Pyruvate kinase isozymes L, MANGANESE (II) ION, CITRATE ANION, ... (10 entities in total) |
Functional Keywords | kinase, glycolysis, allosteric, phosphorylation mimic, liver, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 238311.93 |
Authors | Holyoak, T.,Fenton, A.W. (deposition date: 2013-01-09, release date: 2013-01-30, Last modification date: 2023-09-20) |
Primary citation | Holyoak, T.,Zhang, B.,Deng, J.,Tang, Q.,Prasannan, C.B.,Fenton, A.W. Energetic Coupling between an Oxidizable Cysteine and the Phosphorylatable N-Terminus of Human Liver Pyruvate Kinase. Biochemistry, 52:466-476, 2013 Cited by PubMed: 23270483DOI: 10.1021/bi301341r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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