4IJO

Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases

Summary for 4IJO

Entry DOI	10.2210/pdb4ijo/pdb
Related	1Y93 2OXU
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (4 entities in total)
Functional Keywords	matrix metalloproteinase, hydrolase, degradation of the extracellular matrix proteins, amphiphols, regulatory sites, extracellular
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains	1
Total formula weight	17735.53
Authors	Udi, Y.,Fragai, M.,Grossman, M.,Mitternacht, S.,Arad-Yellin, R.,Calderone, V.,Melikian, M.,Toccafondi, M.,Berezovsky, I.N.,Luchinat, C.,Sagi, I. (deposition date: 2012-12-22, release date: 2013-05-01, Last modification date: 2023-11-08)
Primary citation	Udi, Y.,Fragai, M.,Grossman, M.,Mitternacht, S.,Arad-Yellin, R.,Calderone, V.,Melikian, M.,Toccafondi, M.,Berezovsky, I.N.,Luchinat, C.,Sagi, I. Unraveling hidden regulatory sites in structurally homologous metalloproteases J.Mol.Biol., 425:2330-2346, 2013 Cited by PubMed: 23583775 DOI: 10.1016/j.jmb.2013.04.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation