4IJO
Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Macrophage metalloelastase | polymer | 158 | 17484.5 | 1 | UniProt (P39900) Pfam (PF00413) In PDB | Homo sapiens (human) | MME, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12 |
2 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
4 | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A: 106 - 263 (UniProt: P39900)
PDB | External Database | Details |
---|---|---|
Asp 171 | Phe 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 17484.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 251.1 | |
All* | Total formula weight | 17735.5 |