4IEM

Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+

Summary for 4IEM

• Entry DOI: 10.2210/pdb4iem/pdb
• Related: 4IEK
• Descriptor: DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(*GP*CP*TP*AP*C)-3'), DNA (5'-D(P*(3DR)P*GP*AP*TP*CP*G)-3'), ... (7 entities in total)
• Functional Keywords: metalloprotein, dna damage, dna repair, base excision repair, protein-dna, ref1, nuclease, hydrolase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus. DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion: P27695
• Total number of polymer chains: 16
• Total formula weight: 168495.63

Authors

Tsutakawa, S.E.,Mol, C.D.,Arvai, A.S.,Tainer, J.A. (deposition date: 2012-12-13, release date: 2013-01-23, Last modification date: 2024-02-28)

• Primary citation: Tsutakawa, S.E.,Shin, D.S.,Mol, C.D.,Izumi, T.,Arvai, A.S.,Mantha, A.K.,Szczesny, B.,Ivanov, I.N.,Hosfield, D.J.,Maiti, B.,Pique, M.E.,Frankel, K.A.,Hitomi, K.,Cunningham, R.P.,Mitra, S.,Tainer, J.A.; Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes.; J.Biol.Chem., 288:8445-8455, 2013; PubMed: 23355472; DOI: 10.1074/jbc.M112.422774

Experimental method

X-RAY DIFFRACTION (2.3936 Å)