4IEM

Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I, M (A, B, C, D)	DNA-(apurinic or apyrimidinic site) lyase	polymer	317	35475.3	4	UniProt (P27695) Pfam (PF03372)	Homo sapiens (human)	APEX nuclease, APEN, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1, REF-1, Redox factor-1, DNA-(apurinic or apyrimidinic site) lyase, mitochondrial
2	B, F, J, N (E, H, K, N)	DNA (5'-D(*GP*CP*TP*AP*C)-3')	polymer	5	1480.0	4		Synthetic DNA
3	C, G, K, O (F, I, L, O)	DNA (5'-D(P*(3DR)P*GP*AP*TP*CP*G)-3')	polymer	6	1700.1	4		Synthetic DNA
4	D, H, L, P (G, J, M, P)	DNA (5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*C)-3')	polymer	11	3374.2	4		Synthetic DNA
5	BA, CA, DA, Q, R... (C, D, A, B)	MAGNESIUM ION	non-polymer		24.3	7	Chemie (MG)
6	AA, EA, FA, S, T... (B, D, N, A, E...)	SODIUM ION	non-polymer		23.0	9	Chemie (NA)
7	GA, HA, IA, JA, KA... (A, E, F, G, B...)	water	water		18.0	272	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	168118.6
Non-Polymers*	Number of molecules	16
	Total formula weight	377.0
All*	Total formula weight	168495.6

*Water molecules are not included.