4I77

Lebrikizumab Fab bound to IL-13

Summary for 4I77

• Entry DOI: 10.2210/pdb4i77/pdb
• Descriptor: Lebrikizumab heavy chain, Lebrikizumab light chain, Interleukin-13, ... (4 entities in total)
• Functional Keywords: immunoglobulin, immune system recognition, immune system-cytokine complex, immune system/cytokine
• Biological source: Homo sapiens; More
• Cellular location: Secreted: P35225
• Total number of polymer chains: 3
• Total formula weight: 59650.22

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2012-11-30, release date: 2013-02-06, Last modification date: 2023-09-20)

• Primary citation: Ultsch, M.,Bevers, J.,Nakamura, G.,Vandlen, R.,Kelley, R.F.,Wu, L.C.,Eigenbrot, C.; Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab.; J.Mol.Biol., 425:1330-1339, 2013; PubMed: 23357170; DOI: 10.1016/j.jmb.2013.01.024

Experimental method

X-RAY DIFFRACTION (1.9 Å)