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4I77

Lebrikizumab Fab bound to IL-13

Functional Information from GO Data
ChainGOidnamespacecontents
Z0001774biological_processmicroglial cell activation
Z0002639biological_processpositive regulation of immunoglobulin production
Z0005125molecular_functioncytokine activity
Z0005126molecular_functioncytokine receptor binding
Z0005144molecular_functioninterleukin-13 receptor binding
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005615cellular_componentextracellular space
Z0005737cellular_componentcytoplasm
Z0006954biological_processinflammatory response
Z0006955biological_processimmune response
Z0009612biological_processresponse to mechanical stimulus
Z0009624biological_processresponse to nematode
Z0009897cellular_componentexternal side of plasma membrane
Z0010155biological_processregulation of proton transport
Z0010269biological_processresponse to selenium ion
Z0010628biological_processpositive regulation of gene expression
Z0030890biological_processpositive regulation of B cell proliferation
Z0032496biological_processresponse to lipopolysaccharide
Z0032723biological_processpositive regulation of connective tissue growth factor production
Z0032733biological_processpositive regulation of interleukin-10 production
Z0035094biological_processresponse to nicotine
Z0035772biological_processinterleukin-13-mediated signaling pathway
Z0042116biological_processmacrophage activation
Z0043032biological_processpositive regulation of macrophage activation
Z0043270biological_processpositive regulation of monoatomic ion transport
Z0043306biological_processpositive regulation of mast cell degranulation
Z0045471biological_processresponse to ethanol
Z0045944biological_processpositive regulation of transcription by RNA polymerase II
Z0048661biological_processpositive regulation of smooth muscle cell proliferation
Z0050714biological_processpositive regulation of protein secretion
Z0050728biological_processnegative regulation of inflammatory response
Z0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
Z0071260biological_processcellular response to mechanical stimulus
Z0071345biological_processcellular response to cytokine stimulus
Z0071635biological_processnegative regulation of transforming growth factor beta production
Z0120162biological_processpositive regulation of cold-induced thermogenesis
Z1901247biological_processnegative regulation of lung ciliated cell differentiation
Z1901251biological_processpositive regulation of lung goblet cell differentiation
Z1903660biological_processnegative regulation of complement-dependent cytotoxicity
Z2000231biological_processpositive regulation of pancreatic stellate cell proliferation
Z2000352biological_processnegative regulation of endothelial cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR192-HIS198
HTYR194-HIS200

site_idPS00838
Number of Residues28
DetailsINTERLEUKIN_4_13 Interleukins -4 and -13 signature. LrELIeelvnITqnqkaplCngsmVwSI
ChainResidueDetails
ZLEU10-ILE37

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
ZASN19
ZASN30
ZASN38
ZASN53

226707

PDB entries from 2024-10-30

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