Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4I77

Lebrikizumab Fab bound to IL-13

Functional Information from GO Data
ChainGOidnamespacecontents
Z0001774biological_processmicroglial cell activation
Z0002639biological_processpositive regulation of immunoglobulin production
Z0005125molecular_functioncytokine activity
Z0005126molecular_functioncytokine receptor binding
Z0005144molecular_functioninterleukin-13 receptor binding
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005615cellular_componentextracellular space
Z0005737cellular_componentcytoplasm
Z0005886cellular_componentplasma membrane
Z0006915biological_processapoptotic process
Z0006954biological_processinflammatory response
Z0006955biological_processimmune response
Z0007259biological_processcell surface receptor signaling pathway via JAK-STAT
Z0009612biological_processresponse to mechanical stimulus
Z0009897cellular_componentexternal side of plasma membrane
Z0010155biological_processregulation of proton transport
Z0010628biological_processpositive regulation of gene expression
Z0030890biological_processpositive regulation of B cell proliferation
Z0032496biological_processresponse to lipopolysaccharide
Z0032733biological_processpositive regulation of interleukin-10 production
Z0032905biological_processtransforming growth factor beta1 production
Z0032908biological_processregulation of transforming growth factor beta1 production
Z0035094biological_processresponse to nicotine
Z0035772biological_processinterleukin-13-mediated signaling pathway
Z0042116biological_processmacrophage activation
Z0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
Z0043032biological_processpositive regulation of macrophage activation
Z0043270biological_processpositive regulation of monoatomic ion transport
Z0045471biological_processresponse to ethanol
Z0045944biological_processpositive regulation of transcription by RNA polymerase II
Z0048661biological_processpositive regulation of smooth muscle cell proliferation
Z0050714biological_processpositive regulation of protein secretion
Z0050728biological_processnegative regulation of inflammatory response
Z0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
Z0070371biological_processERK1 and ERK2 cascade
Z0070374biological_processpositive regulation of ERK1 and ERK2 cascade
Z0071260biological_processcellular response to mechanical stimulus
Z0071635biological_processnegative regulation of transforming growth factor beta production
Z0120162biological_processpositive regulation of cold-induced thermogenesis
Z1901247biological_processnegative regulation of lung ciliated cell differentiation
Z1901251biological_processpositive regulation of lung goblet cell differentiation
Z1903660biological_processnegative regulation of complement-dependent cytotoxicity
Z2000231biological_processpositive regulation of pancreatic stellate cell proliferation
Z2000352biological_processnegative regulation of endothelial cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH
ChainResidueDetails
HTYR194-HIS200
LTYR192-HIS198

site_idPS00838
Number of Residues28
DetailsINTERLEUKIN_4_13 Interleukins -4 and -13 signature. LrELIeelvnITqnqkaplCngsmVwSI
ChainResidueDetails
ZLEU10-ILE37

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

PDB statisticsPDBj update infoContact PDBjnumon