4I03

Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor

Summary for 4I03

Entry DOI	10.2210/pdb4i03/pdb
Related	3TS4 3TSK 4EFS 4H30 4H49
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (10 entities in total)
Functional Keywords	selective carboxylate based mmp-12 bifunctional inhibitor, metzincin, zinc protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains	1
Total formula weight	19807.11
Authors	Stura, E.A.,Vera, L.,Devel, L.,Cassar-Lajeunesse, E.,Dive, V. (deposition date: 2012-11-16, release date: 2013-04-24, Last modification date: 2024-02-28)
Primary citation	Antoni, C.,Vera, L.,Devel, L.,Catalani, M.P.,Czarny, B.,Cassar-Lajeunesse, E.,Nuti, E.,Rossello, A.,Dive, V.,Stura, E.A. Crystallization of bi-functional ligand protein complexes. J.Struct.Biol., 182:246-254, 2013 Cited by PubMed: 23567804 DOI: 10.1016/j.jsb.2013.03.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation