4I03

Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	HIS218
A	HIS222
A	HIS228
A	L88306
A	L88306

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	HIS168
A	ASP170
A	HIS183
A	HIS196

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 303

Chain	Residue
A	ASP158
A	GLY190
A	GLY192
A	ASP194
A	HOH414
A	HOH419

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 304

Chain	Residue
A	ASP124
A	GLU199
A	GLU201
A	HOH420
A	HOH429

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 305

Chain	Residue
A	ASP175
A	GLY176
A	GLY178
A	ILE180
A	ASP198
A	GLU201

---

site_id	AC6
Number of Residues	42
Details	BINDING SITE FOR RESIDUE L88 A 306

Chain	Residue
A	GLY179
A	GLY179
A	ILE180
A	ILE180
A	LEU181
A	LEU181
A	ALA182
A	ALA182
A	HIS218
A	HIS218
A	HIS222
A	HIS222
A	HIS228
A	HIS228
A	PRO232
A	PRO232
A	LYS233
A	LYS233
A	ALA234
A	ALA234
A	VAL235
A	VAL235
A	PHE237
A	PHE237
A	PRO238
A	PRO238
A	THR239
A	THR239
A	TYR240
A	TYR240
A	LYS241
A	LYS241
A	ZN301
A	ZN301
A	PGO311
A	PGO311
A	HOH401
A	HOH401
A	HOH513
A	HOH513
A	HOH521
A	HOH521

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 307

Chain	Residue
A	TYR113
A	THR115
A	MET125
A	ASN126
A	ASP129
A	SER150
A	THR204
A	THR205
A	HOH435
A	HOH454
A	HOH468

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 308

Chain	Residue
A	MET105
A	GLY106
A	VAL108
A	ARG110
A	GLY176
A	LYS177
A	SER260
A	LEU261
A	EDO315

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 309

Chain	Residue
A	MET105
A	ASP171
A	GLY225
A	LEU226
A	GLY227
A	SER260
A	LEU261
A	HOH428

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGO A 310

Chain	Residue
A	ARG256

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGO A 311

Chain	Residue
A	TYR240
A	L88306
A	L88306
A	HOH500
A	GLY179
A	THR239

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 312

Chain	Residue
A	HIS172
A	HIS183
A	ALA184
A	EDO316

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 313

Chain	Residue
A	ASP175
A	LYS177
A	GLY178
A	GLY179
A	THR239
A	LYS241
A	EDO315

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 314

Chain	Residue
A	ARG110
A	ASP200
A	EDO315
A	HOH505

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 315

Chain	Residue
A	MET105
A	ASP175
A	PHE237
A	GOL308
A	DMS313
A	EDO314

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 316

Chain	Residue
A	ALA184
A	DMS312
A	HOH401
A	HOH421
A	HOH503

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 317

Chain	Residue
A	HIS168
A	HIS196
A	HOH405

---

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG A 318

Chain	Residue
A	THR145
A	PRO146
A	SER150
A	PHE202
A	HIS206
A	HOH454
A	HOH519
A	HOH520

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE:

Chain	Residue	Details
A	ALA219

---

site_id	SWS_FT_FI2
Number of Residues	19
Details	BINDING:

Chain	Residue	Details
A	ASP124
A	GLY190
A	GLY192
A	ASP194
A	HIS196
A	ASP198
A	GLU199
A	GLU201
A	HIS218
A	HIS222
A	HIS228
A	ASP158
A	HIS168
A	ASP170
A	ASP175
A	GLY176
A	GLY178
A	ILE180
A	HIS183

---