4HW4

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

Summary for 4HW4

Entry DOI	10.2210/pdb4hw4/pdb
Related	4HW2 4HW3 4HW4
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 BH3 peptide (3 entities in total)
Functional Keywords	anti-apoptotic protein, bh3 peptides, apoptosis
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass membrane protein (Potential): Q07820
Total number of polymer chains	4
Total formula weight	39398.73
Authors	Friberg, A.,Zhao, B. (deposition date: 2012-11-07, release date: 2013-01-09, Last modification date: 2013-03-06)
Primary citation	Friberg, A.,Vigil, D.,Zhao, B.,Daniels, R.N.,Burke, J.P.,Garcia-Barrantes, P.M.,Camper, D.,Chauder, B.A.,Lee, T.,Olejniczak, E.T.,Fesik, S.W. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J.Med.Chem., 56:15-30, 2013 Cited by PubMed: 23244564 DOI: 10.1021/jm301448p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation