4HW4
Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 157 | 17850.3 | 2 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (human) | Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT |
| 2 | C, D | Mcl-1 BH3 peptide | polymer | 18 | 1849.1 | 2 | |||
| 3 | water | water | 18.0 | 387 | Chemie (HOH) |
Sequence modifications
A, B: 172 - 327 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 39398.7 | |
| All* | Total formula weight | 39398.7 |
