4HPX
Crystal structure of Tryptophan Synthase at 1.65 A resolution in complex with alpha aminoacrylate E(A-A) and benzimidazole in the beta site and the F9 inhibitor in the alpha site
4HPX の概要
エントリーDOI | 10.2210/pdb4hpx/pdb |
関連するPDBエントリー | 1A5S 2J9X 4HN4 4HPX 4HT3 |
分子名称 | Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (9 entities in total) |
機能のキーワード | lyase, carbon-oxygen lyase, tryptophan biosynthesis, salmonella, f9f, benzimidazole, allosteric enzyme, amino-acid biosynthesis, aromatic amino acid biosynthesis, pyridoxal phosphate, alpha amino acrylate, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
由来する生物種 | Salmonella enterica subsp. enterica serovar Typhimurium 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 73939.43 |
構造登録者 | Hilario, E.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (登録日: 2012-10-24, 公開日: 2013-12-18, 最終更新日: 2023-09-20) |
主引用文献 | Niks, D.,Hilario, E.,Dierkers, A.,Ngo, H.,Borchardt, D.,Neubauer, T.J.,Fan, L.,Mueller, L.J.,Dunn, M.F. Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry, 52:6396-6411, 2013 Cited by PubMed: 23952479DOI: 10.1021/bi400795e 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.65 Å) |
構造検証レポート
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