4GXS

Ligand binding domain of GluA2 (AMPA/glutamate receptor) bound to (-)-kaitocephalin

Summary for 4GXS

• Entry DOI: 10.2210/pdb4gxs/pdb
• Descriptor: Glutamate receptor 2, (5R)-2-[(1S,2R)-2-amino-2-carboxy-1-hydroxyethyl]-5-{(2S)-2-carboxy-2-[(3,5-dichloro-4-hydroxybenzoyl)amino]ethyl}-L-proline, ZINC ION, ... (4 entities in total)
• Functional Keywords: glutamate receptor, glua2, glur2, ampa receptor, neurotransmitter receptor, (-)-kaitocephalin, membrane protein
• Biological source: Rattus norvegicus (brown rat,rat,rats); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 2
• Total formula weight: 58855.43

Authors

Ahmed, A.H.,Oswald, R.E. (deposition date: 2012-09-04, release date: 2012-10-17, Last modification date: 2023-09-13)

• Primary citation: Ahmed, A.H.,Hamada, M.,Shinada, T.,Ohfune, Y.,Weerasinghe, L.,Garner, P.P.,Oswald, R.E.; The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2.; J.Biol.Chem., 287:41007-41013, 2012; PubMed: 23076153; DOI: 10.1074/jbc.M112.416362

Experimental method

X-RAY DIFFRACTION (1.9634 Å)