4GXS

Ligand binding domain of GluA2 (AMPA/glutamate receptor) bound to (-)-kaitocephalin

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 0YS B 301

Chain	Residue
B	TYR61
B	GLU145
B	GLU193
B	HOH454
B	HOH455
B	HOH514
B	HOH550
B	GLY62
B	PRO89
B	LEU90
B	THR91
B	THR93
B	ARG96
B	GLY141
B	SER142

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 302

Chain	Residue
B	GLU42
B	HIS46

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site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 0YS D 301

Chain	Residue
D	LYS60
D	TYR61
D	GLY62
D	PRO89
D	LEU90
D	THR91
D	THR93
D	ARG96
D	LEU138
D	SER140
D	GLY141
D	SER142
D	GLU145
D	GLU193
D	TYR220
D	HOH419
D	HOH484
D	HOH551
D	HOH605

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 302

Chain	Residue
D	GLU42
D	HIS46

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 303

Chain	Residue
B	HIS23
B	GLU30
D	HIS23
D	GLU30

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
B	PRO89
D	SER142
D	THR143
D	GLU193
B	THR91
B	ARG96
B	SER142
B	THR143
B	GLU193
D	PRO89
D	THR91
D	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ARG64
B	ARG148
B	LYS240
D	ARG64
D	ARG148
D	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ILE121
D	ILE121

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER150
D	SER150

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER184
D	SER184

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