4GXS
Ligand binding domain of GluA2 (AMPA/glutamate receptor) bound to (-)-kaitocephalin
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 0YS B 301 |
| Chain | Residue |
| B | TYR61 |
| B | GLU145 |
| B | GLU193 |
| B | HOH454 |
| B | HOH455 |
| B | HOH514 |
| B | HOH550 |
| B | GLY62 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | THR93 |
| B | ARG96 |
| B | GLY141 |
| B | SER142 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | GLU42 |
| B | HIS46 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 0YS D 301 |
| Chain | Residue |
| D | LYS60 |
| D | TYR61 |
| D | GLY62 |
| D | PRO89 |
| D | LEU90 |
| D | THR91 |
| D | THR93 |
| D | ARG96 |
| D | LEU138 |
| D | SER140 |
| D | GLY141 |
| D | SER142 |
| D | GLU145 |
| D | GLU193 |
| D | TYR220 |
| D | HOH419 |
| D | HOH484 |
| D | HOH551 |
| D | HOH605 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN D 302 |
| Chain | Residue |
| D | GLU42 |
| D | HIS46 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 303 |
| Chain | Residue |
| B | HIS23 |
| B | GLU30 |
| D | HIS23 |
| D | GLU30 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
