4GM3
Crystal structure of human WD repeat domain 5 with compound MM-101
Summary for 4GM3
Entry DOI | 10.2210/pdb4gm3/pdb |
Related | 4GM8 4GM9 4GMB |
Related PRD ID | PRD_000895 |
Descriptor | WD repeat-containing protein 5, MM-101 (2 entities in total) |
Functional Keywords | mll1, histone methyltransferase, wd40, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P61964 |
Total number of polymer chains | 16 |
Total formula weight | 280206.59 |
Authors | Karatas, H.,Townsend, E.C.,Chen, Y.,Bernard, D.,Cao, F.,Liu, L.,Lei, M.,Dou, Y.,Wang, S. (deposition date: 2012-08-15, release date: 2013-07-31, Last modification date: 2023-11-15) |
Primary citation | Karatas, H.,Townsend, E.C.,Cao, F.,Chen, Y.,Bernard, D.,Liu, L.,Lei, M.,Dou, Y.,Wang, S. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135:669-682, 2013 Cited by PubMed: 23210835DOI: 10.1021/ja306028q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.393 Å) |
Structure validation
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