4GMB
Crystal structure of human WD repeat domain 5 with compound MM-402
Summary for 4GMB
Entry DOI | 10.2210/pdb4gmb/pdb |
Related | 4GM3 4GM8 4GM9 |
Related PRD ID | PRD_000896 |
Descriptor | WD repeat-containing protein 5, MM-402 (3 entities in total) |
Functional Keywords | mll1, histone methyltransferase, wd40, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P61964 |
Total number of polymer chains | 2 |
Total formula weight | 35024.79 |
Authors | Karatas, H.,Townsend, E.C.,Chen, Y.,Bernard, D.,Cao, F.,Liu, L.,Lei, M.,Dou, Y.,Wang, S. (deposition date: 2012-08-15, release date: 2014-02-19, Last modification date: 2023-11-15) |
Primary citation | Karatas, H.,Li, Y.,Liu, L.,Ji, J.,Lee, S.,Chen, Y.,Yang, J.,Huang, L.,Bernard, D.,Xu, J.,Townsend, E.C.,Cao, F.,Ran, X.,Li, X.,Wen, B.,Sun, D.,Stuckey, J.A.,Lei, M.,Dou, Y.,Wang, S. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J.Med.Chem., 60:4818-4839, 2017 Cited by PubMed: 28603984DOI: 10.1021/acs.jmedchem.6b01796 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.781 Å) |
Structure validation
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