4GL5
Structure of human placental aromatase complexed with designed inhibitor HDDG029 (compound 4)
Summary for 4GL5
Entry DOI | 10.2210/pdb4gl5/pdb |
Related | 3EQM 3S79 3S7S 4GL7 |
Descriptor | Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, (6alpha,8alpha)-6-(but-2-yn-1-yloxy)androsta-1,4-diene-3,17-dione (3 entities in total) |
Functional Keywords | oxidoreductase, estrogen synthetase, cytochrome p450 reductase, er membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Peripheral membrane protein: P11511 |
Total number of polymer chains | 1 |
Total formula weight | 58923.82 |
Authors | Ghosh, D. (deposition date: 2012-08-13, release date: 2012-09-12, Last modification date: 2024-02-28) |
Primary citation | Ghosh, D.,Lo, J.,Morton, D.,Valette, D.,Xi, J.,Griswold, J.,Hubbell, S.,Egbuta, C.,Jiang, W.,An, J.,Davies, H.M. Novel aromatase inhibitors by structure-guided design. J.Med.Chem., 55:8464-8476, 2012 Cited by PubMed: 22951074DOI: 10.1021/jm300930n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.48 Å) |
Structure validation
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