4FI6

Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide

Summary for 4FI6

Entry DOI	10.2210/pdb4fi6/pdb
Related	3HJ0 4FI7 4FI8
Descriptor	Transthyretin, 3-[5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride (3 entities in total)
Functional Keywords	hormone, binding protein, kinetic stabilizer complex, hormone-hormone inhibitor complex, hormone/hormone inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28301.09
Authors	Connelly, S.,Grimster, N.,Wilson, I.A.,Kelly, J.W. (deposition date: 2012-06-08, release date: 2013-02-20, Last modification date: 2023-09-13)
Primary citation	Grimster, N.P.,Connelly, S.,Baranczak, A.,Dong, J.,Krasnova, L.B.,Sharpless, K.B.,Powers, E.T.,Wilson, I.A.,Kelly, J.W. Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate. J.Am.Chem.Soc., 135:5656-5668, 2013 Cited by PubMed: 23350654 DOI: 10.1021/ja311729d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.46 Å)

Structure validation