3HJ0

Transthyretin in complex with a covalent small molecule kinetic stabilizer

Summary for 3HJ0

• Entry DOI: 10.2210/pdb3hj0/pdb
• Related: 3CN1 3CN2 3CN3 3CN4
• Descriptor: Transthyretin, 4-fluorophenyl 3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoate (3 entities in total)
• Functional Keywords: hormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28343.51

Authors

Connelly, S.,Wilson, I.A.,Kelly, J.W. (deposition date: 2009-05-20, release date: 2009-12-22, Last modification date: 2014-11-19)

• Primary citation: Choi, S.,Connelly, S.,Reixach, N.,Wilson, I.A.,Kelly, J.W.; Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.; Nat.Chem.Biol., 6:133-139, 2010; PubMed: 20081815; DOI: 10.1038/nchembio.281

Experimental method

X-RAY DIFFRACTION (1.34 Å)