4FHB
Enhancing DHFR catalysis by binding of an allosteric regulator nanobody (Nb179)
Summary for 4FHB
Entry DOI | 10.2210/pdb4fhb/pdb |
Related | 3K74 |
Descriptor | Dihydrofolate reductase, Nb179, FOLIC ACID, ... (4 entities in total) |
Functional Keywords | nanobody, dihydrofolate reductase, allosteric activator, reductase, oxidoreductase-protein binding complex, oxidoreductase/protein binding |
Biological source | Escherichia coli More |
Total number of polymer chains | 2 |
Total formula weight | 34084.48 |
Authors | Oyen, D. (deposition date: 2012-06-06, release date: 2013-04-24, Last modification date: 2017-11-15) |
Primary citation | Oyen, D.,Wechselberger, R.,Srinivasan, V.,Steyaert, J.,Barlow, J.N. Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli. Biochim.Biophys.Acta, 1834:2147-2157, 2013 Cited by PubMed: 23911607DOI: 10.1016/j.bbapap.2013.07.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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