4FGZ

Crystal Structure of Phosphoethanolamine Methyltransferase from Plasmodium falciparum in Complex with Amodiaquine

Summary for 4FGZ

Entry DOI	10.2210/pdb4fgz/pdb
Descriptor	Phosphoethanolamine N-methyltransferase, 4-[(7-CHLOROQUINOLIN-4-YL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
Functional Keywords	sam-dependent methyltransferase, sam binding, methylation, transferase
Biological source	Plasmodium falciparum
Total number of polymer chains	2
Total formula weight	64550.45
Authors	Lee, S.G.,Alpert, T.D.,Jez, J.M. (deposition date: 2012-06-05, release date: 2012-07-25, Last modification date: 2024-02-28)
Primary citation	Lee, S.G.,Alpert, T.D.,Jez, J.M. Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine. Bioorg.Med.Chem.Lett., 22:4990-4993, 2012 Cited by PubMed: 22771008 DOI: 10.1016/j.bmcl.2012.06.032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.994 Å)

Structure validation