4FGZ
Crystal Structure of Phosphoethanolamine Methyltransferase from Plasmodium falciparum in Complex with Amodiaquine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000234 | molecular_function | phosphoethanolamine N-methyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000234 | molecular_function | phosphoethanolamine N-methyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008654 | biological_process | phospholipid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CQA A 301 |
| Chain | Residue |
| A | PHE29 |
| A | GLU217 |
| A | TYR220 |
| A | HOH448 |
| A | HOH473 |
| A | ILE30 |
| A | PHE31 |
| A | GLY32 |
| A | GLY39 |
| A | GLU42 |
| A | TYR209 |
| A | LEU213 |
| A | VAL216 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CQA A 302 |
| Chain | Residue |
| A | GLU171 |
| A | TYR175 |
| A | GLY243 |
| A | ARG246 |
| A | HOH468 |
| B | GLU96 |
| B | ARG97 |
| B | SER99 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH A 303 |
| Chain | Residue |
| A | TYR19 |
| A | ILE36 |
| A | SER37 |
| A | GLY63 |
| A | ASP85 |
| A | ILE86 |
| A | CYS87 |
| A | ILE90 |
| A | ASN109 |
| A | ASP110 |
| A | ILE111 |
| A | ARG127 |
| A | ASP128 |
| A | ALA129 |
| A | LEU133 |
| A | HOH406 |
| A | HOH415 |
| A | HOH432 |
| A | HOH450 |
| A | HOH472 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 304 |
| Chain | Residue |
| A | GLN18 |
| A | TYR27 |
| A | TYR160 |
| A | TYR175 |
| A | TYR181 |
| A | LYS247 |
| A | HOH481 |
| A | HOH483 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CQA B 301 |
| Chain | Residue |
| B | PHE29 |
| B | ILE30 |
| B | PHE31 |
| B | GLY32 |
| B | GLY39 |
| B | GLU42 |
| B | TYR209 |
| B | LEU213 |
| B | VAL216 |
| B | GLU217 |
| B | TYR220 |
| B | HOH467 |
| B | HOH480 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CQA B 302 |
| Chain | Residue |
| A | GLU96 |
| A | SER99 |
| B | GLU171 |
| B | TYR175 |
| B | GLY243 |
| B | ARG246 |
| B | HOH460 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH B 303 |
| Chain | Residue |
| B | TYR19 |
| B | ILE36 |
| B | SER37 |
| B | GLY63 |
| B | GLY65 |
| B | ASP85 |
| B | ILE86 |
| B | CYS87 |
| B | ILE90 |
| B | ASP110 |
| B | ILE111 |
| B | ARG127 |
| B | ASP128 |
| B | ALA129 |
| B | HIS132 |
| B | HOH406 |
| B | HOH413 |
| B | HOH429 |
| B | HOH441 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 304 |
| Chain | Residue |
| B | GLN18 |
| B | TYR27 |
| B | TYR160 |
| B | TYR175 |
| B | ARG179 |
| B | TYR181 |
| B | LYS247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"22117061","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22117061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25288796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22117061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22771008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25288796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3UJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FGZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R6X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
