4FFZ
Crystal Structure of DENV1-E111 fab fragment bound to DENV-1 DIII (Western Pacific-74 strain).
Summary for 4FFZ
Entry DOI | 10.2210/pdb4ffz/pdb |
Related | 3IRC 4FFZ |
Descriptor | Envelope protein E, DENV1-E111 fab fragment (light chain), DENV1-E111 fab fragment (heavy chain) (3 entities in total) |
Functional Keywords | structural genomics, antibody fab fragment, flavivirus, dengue virus, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, immunoglobulin-like domain, viral envelope protein, virion, immune system, immune system-viral protein complex, immune system/viral protein |
Biological source | Dengue virus 1 (DENV-1) More |
Cellular location | Capsid protein C: Virion. Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P17763 |
Total number of polymer chains | 6 |
Total formula weight | 119059.06 |
Authors | Austin, S.K.,Nelson, C.A.,Fremont, D.H.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-06-01, release date: 2012-06-27, Last modification date: 2023-09-13) |
Primary citation | Austin, S.K.,Dowd, K.A.,Shrestha, B.,Nelson, C.A.,Edeling, M.A.,Johnson, S.,Pierson, T.C.,Diamond, M.S.,Fremont, D.H. Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope. Plos Pathog., 8:e1002930-e1002930, 2012 Cited by PubMed: 23055922DOI: 10.1371/journal.ppat.1002930 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.8 Å) |
Structure validation
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