4FFZ

Crystal Structure of DENV1-E111 fab fragment bound to DENV-1 DIII (Western Pacific-74 strain).

Summary for 4FFZ

• Entry DOI: 10.2210/pdb4ffz/pdb
• Related: 3IRC 4FFZ
• Descriptor: Envelope protein E, DENV1-E111 fab fragment (light chain), DENV1-E111 fab fragment (heavy chain) (3 entities in total)
• Functional Keywords: structural genomics, antibody fab fragment, flavivirus, dengue virus, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, immunoglobulin-like domain, viral envelope protein, virion, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Dengue virus 1 (DENV-1); More
• Cellular location: Capsid protein C: Virion. Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P17763
• Total number of polymer chains: 6
• Total formula weight: 119059.06

Authors

Austin, S.K.,Nelson, C.A.,Fremont, D.H.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-06-01, release date: 2012-06-27, Last modification date: 2023-09-13)

• Primary citation: Austin, S.K.,Dowd, K.A.,Shrestha, B.,Nelson, C.A.,Edeling, M.A.,Johnson, S.,Pierson, T.C.,Diamond, M.S.,Fremont, D.H.; Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope.; Plos Pathog., 8:e1002930-e1002930, 2012; PubMed: 23055922; DOI: 10.1371/journal.ppat.1002930

Experimental method

X-RAY DIFFRACTION (3.8 Å)