4FF8

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)

Summary for 4FF8

• Entry DOI: 10.2210/pdb4ff8/pdb
• Related: 3QUP 4FEQ
• Descriptor: Tyrosine-protein kinase receptor TYRO3, 4-(cyclopentylamino)-2-[(2-methoxybenzyl)amino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide (3 entities in total)
• Functional Keywords: receptor protein tyrosine kinase, phosphotransferase, gas6 (ligand), transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (mouse)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P55144
• Total number of polymer chains: 1
• Total formula weight: 37238.03

Authors

Ohren, J.F.,Powell, N.A.,Kohrt, J.,Perrin, L.A. (deposition date: 2012-05-31, release date: 2013-03-13, Last modification date: 2024-02-28)

Primary citation

Powell, N.A.,Hoffman, J.K.,Ciske, F.L.,Kaufman, M.D.,Kohrt, J.T.,Quin, J.,Sheehan, D.J.,Delaney, A.,Baxi, S.M.,Catana, C.,McConnell, P.,Ohren, J.,Perrin, L.A.,Edmunds, J.J.
Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
Bioorg.Med.Chem.Lett., 23:1046-1050, 2013

PubMed Abstract: We report the SAR around a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. 2-Aminophenethyl analogs demonstrate excellent potency but moderate kinase selectivity, while 2-aminobenzyl analogs that fill the Ala571 subpocket exhibit good inhibition activity and excellent kinase selectivity.

PubMed: 23312472
DOI: 10.1016/j.bmcl.2012.12.013

Experimental method

X-RAY DIFFRACTION (2.4 Å)