4FF8
Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase receptor TYRO3 | polymer | 323 | 36771.4 | 1 | UniProt (P55144) Pfam (PF07714) | Mus musculus (mouse) | Etk2/tyro3, TK19-2, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE |
| 2 | B (A) | 4-(cyclopentylamino)-2-[(2-methoxybenzyl)amino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamide | non-polymer | 466.6 | 1 | Chemie (14S) | |||
| 3 | C (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 485 - 800 (UniProt: P55144)
| PDB | External Database | Details |
|---|---|---|
| Met 484 | - | initiating methionine |
| His 801 | - | expression tag |
| His 802 | - | expression tag |
| His 803 | - | expression tag |
| His 804 | - | expression tag |
| His 805 | - | expression tag |
| His 806 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36771.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 466.6 | |
| All* | Total formula weight | 37238.0 |
