4FF8

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 14S A 901

Chain	Residue
A	ALA571
A	ALA662
A	LEU593
A	PRO594
A	PHE595
A	MET596
A	LYS597
A	GLY599
A	ASP600
A	MET652

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGEFGSVReAqlkqedgsfvk.......VAVK

Chain	Residue	Details
A	LEU514-LYS540

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCML

Chain	Residue	Details
A	PHE641-LEU653

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP645

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU514
A	LYS540

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250

Chain	Residue	Details
A	TYR671
A	TYR675
A	TYR676
A	TYR794

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