4FAE

Substrate p2/NC in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant

Summary for 4FAE

Entry DOI	10.2210/pdb4fae/pdb
Related	1TW7 3OQ7 4FAF
Descriptor	HIV-1 protease, Substrate p2/NC peptide (3 entities in total)
Functional Keywords	protease, viral protein
Biological source	Human immunodeficiency virus 1 More
Cellular location	Capsid protein p24: Virion (By similarity). Matrix protein p17: Virion (By similarity). Nucleocapsid protein p7: Virion (By similarity): Q9YP46
Total number of polymer chains	3
Total formula weight	22376.31
Authors	Wang, Y.,Dewdney, T.G.,Liu, Z.,Reiter, S.J.,Brunzelle, J.S.,Kovari, I.A.,Kovari, L.C. (deposition date: 2012-05-22, release date: 2012-08-29, Last modification date: 2023-07-26)
Primary citation	Wang, Y.,Dewdney, T.G.,Liu, Z.,Reiter, S.J.,Brunzelle, J.S.,Kovari, I.A.,Kovari, L.C. Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease. Biology (Basel), 1:81-93, 2012 Cited by PubMed: 24832048 DOI: 10.3390/biology1010081 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation